Bibliographic data (as of 30th July 2022):
Scientific articles (including reviews): more than 160 (indexed in Web of Science)
Citations: 6010 (5238 without self-citations)
h-index: 46
3 most cited publications:
- Turel, The interactions of metal ions with quinolone antibacterial agents, Coord. Chem. Rev., 2002, 232, 27-47 (478 citations), link
- Rehder, J. C. Pessoa, C. F. G. C. Geraldes, M. M. C. A. Castro, T. Kabanos, T. Kiss, B. Meier, G. Micera, L. Pettersson, M. Rangel, A. Salifoglou, Turel, D. R. Wang, In vitro study of the insulin-mimetic behavior of vanadium(IV,V) coordination compounds, J. Biol. Inorg. Chem., 2002, 7, 384-396 (256 citations), link
- Dimiza, F. Perdih, V. Tangoulis, Turel, D. P. Kessisoglou, G. Psomas, Interaction of copper(II) with the non-steroidal anti-inflammatory drugs napoxen and diclofenac: Synthesis, structure, DNA- and albumin binding, J. Inorg. Biochem., 2011, 105, 476-489 (220 citations), link
Selected publications (from 2015):
2022
Lj. Stevanović, J. Kljun*, I. Aleksic, S. Skaro Bogojevic, D. Milivojevic, A. Veselinović, I. Turel*, M. I. Djuran*, J. Nikodinovic-Runic*, B. Đ. Glišić*, Clinically used antifungal azoles as ligands for gold(III) complexes: The influence of Au(III) ion on the antimicrobial activity of the complex, Dalton Trans., 51, 5322–5344 (2022), doi: https://doi.org/10.1039/D2DT00411A
A. Kostelidou, F. Perdih, J. Kljun, F. Dimou, S. Kalogiannis, I. Turel*, G. Psomas*, Metal(II) complexes of the fluoroquinolone fleroxacin: Synthesis, characterization and biological profile, Pharmaceutics, 14, 898 (2022), doi: https://doi.org/10.3390/pharmaceutics14050898
2021:
N. Lj. Stevanović, I. Aleksic, J. Kljun, S. Skaro Bogojevic, A. Veselinovic, J. Nikodinovic-Runic *, I. Turel *, M. I. Djuran *, B. Đ. Glišić *, Copper(II) and zinc(II) complexes with the clinically used fluconazole: Comparison of antifungal activity and therapeutic potential, Pharmaceuticals, 14, 24 (2021), doi: https://doi.org/10.3390/ph14010024
T. P. Andrejević, I. Aleksic, M. Počkaj, J. Kljun, D. Milivojevic, N. Lj. Stevanović, J. Nikodinovic-Runic, I. Turel, Miloš I. Djuran, and B. Đ. Glišić, Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity, Dalton Trans., 50, 2627–2638 (2021), doi: https://doi.org/10.1039/D0DT04061D
J. Kladnik, J. P. C. Coverdale, J. Kljun, H. Burmeister, P. Lippman, F. G. Ellis, A. M. Jones, I. Ott, I. Romero-Canelón,* and I. Turel*, Organoruthenium Complexes with Benzo-fused Pyrithiones Overcome Platinum Resistance in Ovarian Cancer Cells, Cancers, 13, 2493 (2021), doi: https://doi.org/10.3390/cancers13102493
T. Pivarcsik, G. Tóth, N. Szemerédi, A. Bogdanov, G. Spengler*, J. Kljun, J. Kladnik, I. Turel*, É. A. Enyedy*, Comparison of solution chemical properties and biological activity of ruthenium complexes of selected β-diketone, 8-hydroxyquinoline and pyrithione ligands, Pharmaceuticals, 14, 518 (2021), doi: https://doi.org/10.3390/ph14060518
A. Valente, A. Podolski-Renić, I. Poetsch, N. Filipović, Ó. López, I. Turel, P. Heffeter, Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance, Drug Resist. Updat., 58, 10078 (2021), doi: https://doi.org/10.1016/j.drup.2021.100778
T. Trobec, K. Sepčić*, M. C. Žužek, J. Kladnik, N. Podjed, C. C. Páscoa, I. Turel*, R. Frangež*, Fine tuning of cholinesterase and glutathione-S-transferase activities by organoruthenium(II) complexes, Biomedicines, 9, 1243 (2021), doi: https://doi.org/10.3390/biomedicines9091243
V. D. B. C. Dasireddy*, J. Kladnik, R. Cerc Korošec, B. Likozar* and I. Turel*, Pyrithione Metal (Cu, Ni, Ru) Complexes as Photo-catalysts for Styrene Oxide Production, Sci. Rep., 11, 23810 (2021), doi: https://doi.org/10.1038/s41598-021-03085-2
2020:
T. P. Andrejević, D. Milivojevic, B. Đ. Glišić, J. Kljun, N. L. Stevanović, S. Vojnovic, S. Medic, J. Nikodinovic-Runic, I. Turel, M. I. Djuran, Silver(I) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens, Dalton Trans., 49, 6084–6096 (2020), doi: https://doi.org/10.1039/D0DT00518E
J. Kladnik, S. Ristovski, J. Kljun, A. Defant, I. Mancini, K. Sepčić,* and Iztok Turel,*, Structural Isomerism and Enhanced Lipophilicity of Pyrithione Ligands of Organoruthenium(II) Complexes Increase Inhibition on AChE and BuChE, Int. J. Mol. Sci., 21, 5628 (2020), doi: https://doi.org/10.3390/ijms21165628
2019:
J. Kladnik, J. Kljun, H. Burmeister, I. Ott, I. Romero-Canelón, I. Turel, Towards identification of essential structural elements of organoruthenium(II)-pyrithionato complexes for anticancer activity, Chem. Eur. J. 2019, 25, 14169-14182, doi:10.1002/chem.201903109
A. Mitrović and J. Kljun, I. Sosič, M. Uršič, A. Meden, S. Gobec, J. Kos, I. Turel, Organoruthenated nitroxoline derivatives impair tumor cell invasion through inhibition of cathepsin B activity, Inorg. Chem. 2019, 58, 12334-12347, link
M.C. Ruiz, J. Kljun, I. Turel, A. L. Di Virgilio, I. E. Leon, Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone, lung and breast cancer, Metallomics 2019, 11, 666-675, link
M. Pernar, Z. Kokan, J. Kralj, Z. Glasovac, L.-M. Tumir, I. Piantanida, D. Eljuga, I. Turel, A. Brozović, S. I. Kirin, Organometallic ruthenium(II)-arene complexes with triphenylphosphine amino acid bioconjugates: Synthesis, characterization and biological properties, Bioorg. Chem. 2019, 87, 432-446, link
Y. P. Sheng, Z. H. Hou, S. Y. Cui, K. M. Cao, S. M. Yuan, M. Sun, J. Kljun, G. M. Huang, I. Turel, Y. Z. Liu, Covalent versus noncovalent binding of ruthenium η6–p-cymene complexes to zinc-finger protein NCp7, Chem. Eur. J. 2019, doi:10.1002/chem.201902434
A. Briš, J. Jašík, I. Turel and J. Roithová, Anti-cancer organoruthenium(II) complexes and their interactions with cysteine and its analogues. A mass-spectrometric study, Dalton Transactions, 2019, 48, 2626–2634, link
S. Seršen, K. Traven, J. Kljun, I. Turel, C. T. Supuran, Organoruthenium(II) complexes of acetazolamide potently inhibit human carbonic anhydrase isoforms I, II, IX and XIIM, J. Enzyme Inhib. Med. Chem. 2019, 34, 388-393, link
2018:
A. Briš, I. Turel, J. Roithova, C-H bond activation by a ruthenium(II) β-diketonate complex: A mechanistic study, Eur. J. Org. Chem. 2018, 6107-6113, link
S. Ristovski, M. Uzelac, J. Kljun, T. Lipec, M. Uršič, Š. Zemljič Jokhadar, M. C. Žužek, T. Trobec, R. Frangež, K. Sepčić, I. Turel, Organoruthenium prodrugs as a new class of cholinesterase and glutathione-S-transferase inhibitors, ChemMedChem 2018, 13, 2166-2176, link
J. Kljun, I. E. Leon, Š. Peršič, J. F. Cadavid-Vargas, S. B. Etcheverry, W. J. He, Y. Bai, I. Turel, Synthesis and biological characterization of organoruthenium complees with 8-hydroxyquinolines, J. Inorg. Biochem. 2018, 186, 187-196, link
K. Traven, I. Turel, J. Kožíškova, L. Bučinský, J. Kožíšek, Concomitant polymorphism in an organometallic ruthenium(II) complex with an N,N’-donor ligand, Acta Cryst. C. – Struct. Chem. 2018, C74, 683-689, link
Z. Sochorová Vokáčová, I. Turel, J. V. Burda, Exploration of selecte electronic characteristics of half-sandwich organoruthenium(II) β-diketonate complexes, J. Mol. Model. 2018, 24, 98, link
M. Živković. J.Kljun, T. Ilić-Tomić, A. Pavić, A. Veselinović, D. D. Manojlović, J. Nikodinović-Runić, I. Turel, A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity, Inorg. Chem. Front. 2018, 5, 39-53, link
2017:
M .Uršič, T. Lipec, A. Meden, I. Turel, Synthesis and Structural evaluation of Organo-Ruthenium Complexes with β-Diketonates, Molecules 2017, 22, 326 doi: 10.3390/molecules22020326
J. Kljun, I. Turel, β-Diketones as Scaffolds for Anticancer Drug Design – From Organic Building Blocks to Natural Products and Metallodrug Components, Eur. J. Inorg. Chem. 2017, 12, 1655–1666 doi: 10.1002/ejic.201601314
2016:
T. Zábojníková, R. Cajzl, J. Kljun, Z. Chval, I. Turel, J. V. Burda, Interactions of the ”piano-stool” [ruthenium(II)(η6-arene)(quinolone)Cl]+complexes with water; DFT computational study, J. Comput. Chem. 2016, 37, 1766-1780 doi:10.1002/jcc24373
A. Mitrović, J. Kljun, I.Sosič, S. Gobec, I. Turel and J. Kos, Clioquinol–ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity, Dalton Trans. 2016, 45, 16913-16921 doi: 10.1039/C6DT02369J
J. Kljun, M. Anko, K. Traven, M. Sinreih, R. Pavlič. Š. Peršič, Ž. Ude, E. E. Codina, J. Stojan, T. Lanišnik Rižner, I. Turel, Pyrithione-based ruthenium complexes as inhibitors of aldo–keto reductase 1C enzymes and anticancer agents, Dalton Trans. 2016, 45, 11791-11800 doi: 10.1039/C6DT00668J
S. Seršen, P. Šket, J. Plavec, I. Turel, Interactions of two cytotoxic organoruthenium(II) complexes with G-quadruplex, J. Inorg. Biochem. 2016,170, 70-77 doi: 10.1016/j.jinorgbio.2015.11.012
K Traven, N. Eleftheriadis, S. Seršen, J. Kljun, J. Bezenšek, B. Stanovnik, I. Turel, F. J. Dekker, Ruthenium complexes as inhibitors of 15-lipoxygenase-1, Polyhedron 2016, 101, 306-313, link
2015:
S. Seršen, J. Kljun, K. Kryeziu, R. Panchuk, B. Alte, W. Körner, P. Heffeter, W. Berger, I. Turel, Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates. J. Med. Chem. 2015, 58, 3984–3996, doi: 10.1021/acs.jmedchem.5b00288
K. Traven, M. Sinreih, J. Stojan, S. Seršen, J. Kljun, J. Bezenšek, B. Stanovnik, I. Turel, T. Lanišnik Rižner, Ruthenium complexes as inhibitors of the aldo-keto reductase 1C enzymes AKR1C1-AKR1C3, Chem.-Biol. Inter. 2015, 234, 349–35, doi: 10.1016/j.cbi.2014.11.005
Summary of education:
BSc Chemistry (1989)
MSc Chemistry (1991)
PhD Chemistry (1995)
all titles at the Faculty of Chemistry and Chemical Technology, University of Ljubljana (FKKT, UL)
Academic career:
1989-1997, Assistant at the Chair of Inorganic Chemistry (FKKT, UL)
1997-2003, Assistant Professor at the Chair of Inorganic Chemistry
2003-2008, Associate Professor at the Chair of Inorganic Chemistry
2008-ongoing, Full Professor at the Chair of Inorganic Chemistry
2009-2017, Head of Chair of Inorganic Chemistry
Research projects and programmes:
1996-2001, “Study of novel quinolone-metal complexes”, project funded by Slovenian ministry of Science and Technology. Principal investigator.
1997-1999, “Organometallic compounds of the group 4 elements (Ti, Zr, Hf) with fluorides and quinolones”, project funded by Slovenian research agency. Member.
1999-ongoing, “Synthesis, structure and properties of matter and materials” programme grant funded by Slovenian research agency. Member.
2008-2011, “Synthesis of novel ruthenium compounds and their potential use in electrochemotherapy of tumors“, project funded by Slovenian research agency. Principal investigator.
2009-2013, “NMR Center of excellency for research in biotechnology, pharmacy and physics (CO EN-FIST)“. Founding member.
2011-2014, “Synthesis, characterisation and use of novel ruthenium compounds in electrochemotherapy of tumors“, project funded by Slovenian research agency. Principal investigator.
2014-2016, “New targets for old drugs. Organoruthenium derivatives of hydroxyquinolines and beta-carbolines as potential anticancer drugs“. Postdoctoral project of dr. Jakob Kljun. Host researcher.
2020-2021, “Metallo-Therapeutics to Combat COVID-19 Disease”, funded by Slovenian research agency. Principal investigator.
Research interests:
Biological inorganic chemistry, coordination and organometallic chemistry, medicinal chemistry, development of anticancer compounds,metal based drugs, catalysis.
Member of editorial boards:
Molecules (2003-)
Frontiers in Chemistry (2013-)
Journal of Coordination Chemistry (2015-)
Other positions:
2004-2017, Coordinator for international cooperation and Coordinator for Lifelong Learning (Socrates-Erasmus) Programme at FKKT UL
2005-ongoing, Slovenian delegate in the division of “Chemistry in Life Sciences” in European Association for Chemical and Molecular Sciences EuCheMS
2006-2010, Member of discussion group (Natural Sciences, Chemistry) at Slovenian Research Agency
2010-2014, COST Domain Expert (Chemistry and Molecular Sciences and Technologies)
2011-2017, Member of the senate of FKKT UL
2011, Member of the national committee of International year of chemistry
2012-ongoing, Slovenian representative Inorganic Division of EuCheMS
2013-2017, President of the committee for international cooperation at University of Ljubljana
2017-ongoing, Management Committee Board UL FKKT