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Turel Group and Rhenium
Our main focus is still on ruthenium complexes; however, in recent years we have also started to explore rhenium [1–3]. Historically, rhenium primarily served as a chemical analogue for technetium, as it has similar chemistry and stable isotopes. This allowed researchers to study technetium-based radiopharmaceuticals without the risks and limitations associated with radioactive materials. In […]
Metal based compounds as drugs against many diseases
People were using metals and metal compounds for the treatment of various diseases for millennia. Nowadays chemists rationally synthesise metal complexes with the aim to use them in medical practice. Without any doubt, the most well-known drug of this type is cisplatin which is a famous anticancer drug. In our labs the most efforts were […]
Ruthenium anticancer complexes. Looking for possible targets and further insights into the mechanisms of action.
This year we have continued with research on versatile ruthenium compounds and several publications were successfully published. Promising research on pyrithione complexes was continued within doctoral study of Jerneja Kladnik. Several novel pyrithione analogues were prepared and characterized, extensive biological tests were performed in the cooperation with dr. I. Romero-Canelón (University of Birmingham, UK) and […]
150th anniversary of the periodic table of chemical elements. Periodic table, Mendeleev and philately.
Russian chemist Dmitri I. Mendeleev (1834–1907) has formulated the periodic system of chemical elements (PSCE) in 1869. Frequently, this is considered as one of the greatest inventions in chemistry. The year 2019 marks the 150th anniversary of this discovery and has thus been proclaimed the “International Year of the Periodic Table of Chemical Elements (IYPT2019)” […]
Our study on inhibition of cholinesterases and glutathione-S-transferases by organoruthenium complexes selected for cover feature in October 2018 edition of ChemMedChem
In this paper , a library of 17 organoruthenium compounds was screened for inhibitory activity against cholinesterases and glutathione-S-transferases of human and animal origins. The cover feature picture (see below) shows an organoruthenium-pyrithione complex which inhibits cholinesterases and glutathione-S-transferases at pharmaceutically relevant concentrations while we observed no undesirable physiological responses on the neuromuscular system as well […]
Our study on concomittant polymorphism selected for cover page in June 2018 edition of Acta Crystallographica, Section C
Polymorphism is a well-known phenomenon and represents the ability of a solid material to exist in more than one form. It is not only important from the academic point of view but has also many practical applications or consequences. A typical example is the pharmaceutical industry where many drugs receive regulatory approval for only one […]
Spring in Ru lab
Several interesting and important things have happened in our group during spring 2018. During his short stay at our Faculty, Prof. Bostjan Kobe has shortly visited our labs. Bostjan and Iztok were classmates during their study of chemistry at the Univerity of Ljubljana. Bostjan later went to University of Texas Soutwestern America Medical Center at […]
Viva Voce examination at Royal College of Surgeons in Ireland
In mid March Prof. I. Turel was invited to act as external reviewer of Ph.D. thesis and Viva Voce examiner at Royal College of Surgeons in Ireland (RCSI). In this thesis D. Keogan has studied metallohydroxamates as novel anti-bacterial and anti-leishmanial agents under supervision of Dr. D. Griffith (Department of Pharmaceutical & Medicinal Chemistry). It […]
Chapter in book »Ruthenium Complexes: Photochemical and Biomedical Applications«
A book entitled »Ruthenium Complexes: Photochemical and Biomedical Applications« (ISBN: 978-3-527-33957-0) was recently published by Wiley-VCH (Weinheim). The book consists of 15 chapters (344 pages). The content of book is covering many interesting properties of this popular element and spans from coordination chemisty of ruthenium to photochemical and photophysical properties of its compounds. The book […]
Prolific 2017 for former postdoc Božidar
During his one-year postdoc in our labs Božidar Čobeljić introduced Schiff base ligands to our research group. Fruitful cooperation with Belgrade group in last years results in several recent papers which focus on the systemic synthesis and studies of heterocyclic Schiff base ligands of Girard’s reagents and their 3d metal complexes. Further papers are in […]